SPYRE THERAPEUTICS INC

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SYRE·00773J202·US·equity·Healthcare - Biotechnology-Activist

SYRE (SPYRE THERAPEUTICS INC) is held by 109 institutional investors as of Q1 2026. Largest holders: FMR LLC ($594.2M), BlackRock, Inc. ($278.5M), RTW INVESTMENTS, LP ($210.4M). Net institutional sentiment: Bullish.

109

Holders

Avg rating(7 Elite)

$2.5B

Total Value

68% (111)

Fund Consensus

70 buying - 33 selling

Smart Money Verdict

View all

43Weak MomentumSplit Signals

Institutional (13F)67

Insider (Form 4)0

Activist (13D/13G)51

Congressional (STOCK Act)

No data

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See how SYRE's score breaks down across 4 SEC sources

Holder Quality

7

★★★★★

Elite

37

★★★★

Strong

28

★★★

Solid

32

★★

Below

7

★

Weak

Held by 109 funds

7 elite

Who's Trading

InsiderHTHENDERSON MICHAEL THOMASSell $174KMay 8, 2026

13F: Mar 31, 2026Insider & Congress: Updated regularly

Positions (111)History

AllNewIncreasedHeldDecreasedExited

Fund	Action	Shares	Value	Weight	Est. P&L	Conviction
FMR LLC	Increased	11.8M(+1.2%)	$594.2M	0.0%	+203.44%	32
BlackRock, Inc.	Decreased	5.5M(-0.0%)	$278.5M	0.0%	+206.70%	0
RTW INVESTMENTS, LP	Unchanged	4.2M	$210.4M	2.1%	+219.30%	0
DRIEHAUS CAPITAL MANAGEMENT LLC	Decreased	2.8M(-3.2%)	$140.8M	1.0%	+220.15%	0
STATE STREET CORP	Increased	2.6M(+15.2%)	$131.5M	0.0%	+171.81%	35
WELLINGTON MANAGEMENT GROUP LLP	Increased	1.8M(+17.8%)	$92M	0.0%	+169.08%	35
Capital International Investors	Decreased	1.7M(-50.0%)	$88.1M	0.0%	+235.51%	0
GEODE CAPITAL MANAGEMENT, LLC	Increased	1.7M(+3.7%)	$86.8M	0.0%	+169.92%	31
JANUS HENDERSON GROUP PLC	Decreased	1.7M(-9.4%)	$83.6M	0.0%	+135.37%	0
RA CAPITAL MANAGEMENT, L.P.	Unchanged	1.6M	$81.8M	0.9%	+135.01%	0
BANK OF AMERICA CORP /DE/	Increased	1.2M(+192.6%)	$61.9M	0.0%	+124.45%	48
BAKER BROS. ADVISORS LP	Unchanged	1M	$50.4M	0.3%	+378.86%	0
FRANKLIN RESOURCES INC	Decreased	882,833(-20.4%)	$44.5M	0.0%	+197.48%	0
JPMORGAN CHASE & CO	Increased	979,299(+1455.7%)	$44.5M	0.0%	+94.11%	47
Polar Capital Holdings Plc	Increased	792,847(+7.1%)	$40M	0.1%	+284.32%	37
UBS Group AG	Decreased	671,235(-1.4%)	$33.9M	0.0%	+188.67%	0
Capital World Investors	Increased	666,564(+233.0%)	$33.6M	0.0%	+115.25%	47
Candriam S.C.A.	Increased	610,282(+43.4%)	$30.8M	0.2%	+156.59%	46
NORTHERN TRUST CORP	Increased	578,907(+3.2%)	$29.2M	0.0%	+166.37%	30
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	Decreased	562,653(-2.1%)	$28.4M	0.0%	+173.55%	0